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Customer Stories Featuring CyTOF Technology for Mass Cytometry

Mass cytometry, powered by CyTOF® technology, is the world’s most advanced single-cell proteomics technology. It has opened new doors to discovery by empowering researchers to interrogate more than 50 markers simultaneously on millions of individual cells to unveil new cell types, functions and biomarkers in immunology, cancer, stem cells and more. Below are interviews with a few researchers who are driving groundbreaking discoveries, one CyTOF at a time.

» Access CyTOF mass cytometry resources

A revelation in cancer cell behavior: The NK cell story | Wendy Fantl, PhD
On the right path to better ovarian cancer diagnosis and treatment

Related products: Helios, CyTOF XT
Related application or research area: immuno-oncology
Uncovering immunological mechanisms of protection | Marcelo Sztein, MD
Research focuses on infection, vaccination in humans

Related products: Helios
Related application or research area: clinical studies, vaccination development, CyTOF, immune response, epigenetics
Research links cell signaling, location and patient prognosis in brain tumors | Rebecca Ihrie, PhD
How CyTOF technology enabled a look into the heterogeneity of glioblastoma

Related products: Helios, Hyperion Imaging System
Related application or research area: Brain cancer, glioblastoma, neuropathology, CyTOF, phenotyping
Moving forward with mass cytometry in the midst of the pandemic | Lori Turner, PhD
A quick pivot to COVID-19 research with CyTOF

Related products: Maxpar® Direct™ Immune Profiling Assay™, Maxpar Pathsetter software, Helios
Related application or research area: COVID-19, immune cells, clinical trials, CyTOF, inflammation, immune profiling
Battling pathogens, from HIV to SARS-CoV-2 | Nadia Roan, PhD
UCSF researcher focuses on immune system responses

Related products: Helios
Related application or research area: HIV, signaling, CyTOF, immune cells, COVID-19
Enabling better insight | Xianting Ding, PhD
High-dimensional single-cell analysis enhances precision medicine

Related products: Hyperion Imaging System, Helios
Related application or research area: Combinatorial drug therapies, biomarker discovery, immune profiling, dual-mode capability, immune cells
CyTOF Reveals Immune Disruption | Benjamin Terrier, MD, PhD
Discovering a hallmark phenotype of COVID-19

Related products: Helios, Maxpar® Direct™ Immune Profiling Assay™, Maxpar Pathsetter software
Related application or research area: COVID-19, disease mechanism, adaptive immune response, signaling, autoimmune diseases
Extending a global understanding of COVID-19 | Dr. Dexi Chen, PhD, MD
Achieving multi-omic insights with microfluidics and CyTOF technology

Related products: Hyperion Imaging System, Helios, Juno, Biomark HD
Related application or research area: COVID-19, dual-mode capability, immunology, infiltration, disease progression, immune cells
COVID-19, cardiovascular disease and mass cytometry | Hema Kothari, PhD
A lesson in how CyTOF technology can empower flexibility in research

Related products: Helios
Related application or research area: COVID-19, Cardiovascular disease, chronic inflammatory disease, cytokine storm, CyTOF
Machine Learning and Infectious Disease | Adriana Tomic, PhD
Adriana Tomic on the role machine learning is playing in vaccine development

Related products: Helios
Related application or research area: Immune response, vaccine responses, infectious disease
Deciphering T Cell Diversity in the Tumor Microenvironment | Evan Newell, PhD
Evan Newell on decoding immune cell heterogeneity with mass cytometry

Related products:
Related application or research area: Tumor microenvironment, biomarker discovery, phenotyping, immunotherapy
A Visionary Call to Action | Sonia Gavasso, PhD
Sonia Gavasso on the potential for mass cytometry to improve immunotherapy

Related products: Helios
Related application or research area: neurobiology, immunotherapy, immune profiling, clinical trials
The Long Game | John Daley
How John Daley leverages mass cytometry in his 36-year career fighting against cancer

Related products: Helios
Related application or research area: acute lymphoid leukemia, CyTOF, cytometry
Exploring "Impossible" Science | Eli Zunder, PHD
CyTOF and mass-tag barcoding let Eli Zunder ask more questions and find new answers

Related products: Helios
Related application or research area: stem cells, barcoding, CyTOF
Immune Signatures Predict Surgery Recovery | Brice Gaudillière, MD, PhD
A researcher on the fast track to developing an immune system fitness test

Related products: Helios
Related application or research area: transcription factors, CyTOF, surgical recovery
Passion, Imagination & CyTOF | Sean Bendall, PhD
In the Field: How Sean Bendall is advancing Stanford proteomics research

Related products: Helios
Related application or research area: CyTOF, single-cell, signalling,stem cell, blood cancer

Customer Stories Featuring the Hyperion Imaging System for Imaging Mass Cytometry

Researchers the world over are choosing to do their high-multiplex imaging and single-cell protein analysis experiments on the Hyperion™ Imaging System for Imaging Mass Cytometry™ in order to spatially analyze the tissue microenvironment with single-cell resolution.

» Learn how Imaging Mass Cytometry works

Cancer, autoimmunity and COVID-19 | Yongpan Yan, PhD
Using Imaging Mass Cytometry to define the diversity within cell response

Related products: Hyperion Imaging System
Related application or research area: CyTOF, immunology, pathology, tumor microenvironment, COVID-19, immunotherapy, oral cancer
Immune response to KRAS inhibition | Febe Van Maldegem, PHD
Imaging the dramatic remodeling of the lung tumor microenvironment

Related products: Hyperion Imaging System, IMC Cell Segmentation Kit
Related application or research area: signaling, tumor microenvironment, bioinformatics, immunotherapy
Breast cancer disparities and tumor biology | Melissa Davis, PhD
Defining spatial characteristics using Imaging Mass Cytometry

Related products: Hyperion Imaging System
Related application or research area: breast cancer, phenotyping, inflammation
Research links cell signaling, location and patient prognosis in brain tumors | Rebecca Ihrie, PhD
How CyTOF technology enabled a look into the heterogeneity of glioblastoma

Related products: Helios, Hyperion Imaging System
Related application or research area: Brain cancer, glioblastoma, neuropathology, CyTOF, phenotyping
Enabling better insight | Xianting Ding, PhD
High-dimensional single-cell analysis enhances precision medicine

Related products: Hyperion Imaging System, Helios
Related application or research area: Combinatorial drug therapies, biomarker discovery, immune profiling, dual-mode capability, immune cells
Extending a global understanding of COVID-19 | Dr. Dexi Chen, PhD, MD
Achieving multi-omic insights with microfluidics and CyTOF technology

Related products: Hyperion Imaging System, Helios, Juno, Biomark HD
Related application or research area: COVID-19, dual-mode capability, immunology, infiltration, disease progression, immune cells
Unlocking Topographic Biomarkers | Denis Schapiro
The interactive histoCAT toolbox unifies the cytometry and imaging communities

Related products: Hyperion Imaging System
Related application or research area: computational biology, bioinformatics, cancer, method development
Unraveling the Biology of Cancer | Bernd Bodenmiller, PhD
Bernd Bodenmiller on revealing new insights into tumors with Imaging Mass Cytometry

Related products: Hyperion Imaging System
Related application or research area: tumor microenvironment, cancer, method development, phenotyping
Getting the Whole Pathology Picture | David L. Rimm, MD, PhD
David Rimm on the value of Imaging Mass Cytometry for immunology applications at Yale

Related products: Hyperion Imaging System
Related application or research area: CyTOF, Imaging, biomarker discovery

Customer Stories Featuring Microfluidics Technology for Genomics, Gene Expression and Single-Cell Analysis

From developing bimodal single-cell omics and tumor profiling at single-cell resolution to integrating transcriptional data and cellular function, labs all around the globe are leveraging the nanoscale reactions made possible with Fluidigm integrated fluidic circuit (IFC) technology. Read articles below featuring researchers who are using microfluidics for maximum data and insights.

» Research area spotlight: Ag-genomics—A look at the latest agricultural biology DNA sampling applications and approaches

Extending a global understanding of COVID-19 | Dr. Dexi Chen, PhD, MD
Achieving multi-omic insights with microfluidics and CyTOF technology

Related products: Hyperion Imaging System, Helios, Juno, Biomark HD
Related application or research area: COVID-19, dual-mode capability, immunology, infiltration, disease progression, immune cells
Coupling immunology and microfluidics | Luc Teyton, MD, PhD
How one lab explores the immune system one T cell at a time

Related products: C1 System, Biomark HD, Juno
Related application or research area: autoimmunity, immune cells, type 1 diabetes, inflammatory bowel diseases
The intestinal stem cell response | Scott Magness, PhD
Investigating transcriptomic changes at the microscale level

Related products: Advanta RNA-Seq NGS Library Prep Kit
Related application or research area: stem cells, genetic mechanisms, hypoxia, microdevices, method develoment
Correlating cause and consequence in single-cell systems| Jan-Philipp Mallm, PhD
A look into the epigenetics and mechanisms of action behind cancer and therapy

Related products: C1 System
Related application or research area: cancer genome, single-cell sequencing, epigenome, IFC, neurobiology, method develoment
Integrating transcriptional data and cellular functiont | Simone Mayer, PhD
How using multimodal analysis helped reveal new insights

Related products: C1 System, Polaris™ system
Related application or research area: neurobiology, stem cells, single-cell sequencing
DNA Fingerprinting at a Genetics Biorepository | Kelly Nudelman, PhD
Kelly Nudelman and Tae-Hwi Schwantes-An discuss sample identification

Related products: Juno, Biomark HD
Related application or research area: DNA fingerprinting, Biobank, microfluidicss workflow
Characterizing the Transcriptome | Jo Vandesompele, PhD
Jo Vandesompele at Ghent University discusses a deep dive into single-cell sequencing

Related products: C1 System
Related application or research area: single-cell sequencing, transcriptomics, non-coding RNA, method development
Striking Balance in Throughput and Resolution | Christophe Lancrin, PhD
On revealing new transcription factors using C1 and Biomark

Related products: C1 System, Biomark HD
Related application or research area: single-cell sequencing, transcriptomics, stem cells, transcription factors
Developing Bimodal Single-Cell Omics | Ansuman Satpathy, MD, PhD
Stanford’s Ansu Satpathy designed single-cell T-ATAC-seq, now available at Script Hub

Related products: C1 System, ScriptHub, Open App IFCs
Related application or research area: immune response, cancer, epigenetics, method development, immunotherapy
Tumor Profiling at Single-Cell Resolution | Shyam Prabhakar, PhD
Shyam Prabhakar explores signatures of patient survival and EMT in colorectal tumors

Related products: C1 System
Related application or research area: single-cell transciptome, colorectal cancer, single-cell RNA sequencing
Cracking the Immunity Code | Quinn Wills, Kenny Moore, Rory Bowden (University of Oxford)
Oxford scientists discern macrophage signaling roles in HIV latency using Polaris

Related products: Polaris
Related application or research area: HIV, macrophages, heterogeniety
Linking T Cell Clonotype to Phenotype | Michael Stubbington, PhD, and Tapio Lönnberg, PhD
A new single-cell sequencing tool brings fresh insight to functional T cell studies

Related products: C1 platform
Related application or research area: T cells, population analysis, tumor immunology
The Single-Cell Analysis Technologist | Charles Gawad, MD, PhD
Burroughs Wellcome Fund honors Charles Gawad’s genomics mission for pediatric biology

Related products: C1 platform
Related application or research area: acute lymphoblastic leukemia, pediatriac cancer, single-cell analysis
Breakthroughs | Will Greenleaf, Sten Linnarsson, Alex Shalek
Groundbreaking discoveries made by the single-cell community

Related products: C1 platform, Script Hub
Related application or research area: single-cell RNA Seq
One Artist’s Scientific Method | Fabian Oefner
Fabian Oefner exposes beautiful unseen moments of daily life

Related application or research area: art
Tie a Pink Ribbon on Breast Cancer Treatment | Jiannis Ragoussis, PhD
Single-cell exome sequencing reveals cell population insights for better therapies

Related products: C1 platform
Related application or research area: breast cancer, single-cell sequencing, mutations, circulating tumor cells
At the Frontier of Wolf Conservation Research | Robert Kraus, PhD
Robert Kraus advances field efforts using SNP genotyping

Related products: EP1 System
Related application or research area: single-nucleotide polymorphism, genotyping
Pioneering Immune Therapy Research | Benaroya Research Institute at Virginia Mason (BRI), Seattle
In the Field: Benaroya Research Institute’s pioneering quest into autoimmune disease

Related products: C1 Platform
Related application or research area: multi-discliplinary, immune therapy, immune cells
Determining RNA’s Impact | Dr. Gene Yeo
Gene Yeo’s lab is unraveling stem cell survival, renewal & differentiation

Related products: C1 Platform, Biomark HD
Related application or research area: embryonic stem cells, neurobiology, heterogeniety
Understanding Central Immune System Cells | Mario Roederer, PhD
Mario Roederer discusses his NIH research characterizing HIV-treatment immunology

Related products: Biomark
Related application or research area: pathogenesis, vaccine development, T cells
Discovering stem cell and mRNA sequencing transcriptomes for regenerative medicine | Akira Watanabe, PhD
This Lab at Kyoto University paved the way for stem cell research with the world’s first generation of mouse and human iPSCs

Related products: C1 System
Related application or research area: stem cells, heterogeniety
Pioneering Progress in Cancer Immunotherapy | MD Anderson Cancer Center
Single-cell genomics advances T cell immunotherapies at MD Anderson Cancer Center

Related products: C1 System, Biomark, Delta Gene Assay Panels
Related application or research area: T cells
Exploring novel insights into cancer’s molecular origins | Dr. Stephen Quake
This lab at Stanford University is among the first to pioneer the use of microfluidic tools to study single-cell genomics

Related products: Biomark HD, C1 System
Related application or research area: cancer stem cells, colorectal cancer, heterogeniety
Developing stem cell treatments at Cambridge Institute for Medical Research | Bertie Göttgens (The Haematopoietic Stem Cell Lab)
This lab is based in the Cambridge Institute for Medical Research, and forms part of the Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute

Related products: Biomark HD, C1 System
Related application or research area: stem cells, transcription factors