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Automated cell type discovery and classification through knowledge transfer

Lee, H.C., Kosoy, R., Becker, C.E. et al.

Recent advances in mass cytometry allow simultaneous measurements of up to 50 markers at single-cell resolution. However, the high dimensionality of mass cytometry data introduces computational challenges for automated data analysis and hinders translation of new biological understanding into clinical applications. Previous studies have applied machine learning to facilitate processing of mass cytometry data. However, manual inspection is still inevitable and becoming the barrier to reliable large-scale analysis.

Citation

Lee, H.C., Kosoy, R., Becker, C.E. et al. "Automated cell type discovery and classification through knowledge transfer" Bioinformatics (2017): 1,689-1,695