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CYP gene expressions in obesity-associated metabolic syndrome

Tabur, S., Oztuzcu, S., Oguz, E. et al.

PURPOSE:
The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study.

METHODS:
A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system.

RESULTS:
We observed marked suppressions in CYP2A6 (p=0.0123), CYP4F2 (p=0.0005), CYP3A5 (p=0.0003), and CYP17A1 (p<0.0001) gene expressions in MetS patients.

CONCLUSIONS:
This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS.

Citation

Tabur, S., Oztuzcu, S., Oguz, E. et al. "CYP gene expressions in obesity-associated metabolic syndrome" Obesity Research and Clinical Practice (2016): 719–23