CYP gene expressions in obesity-associated metabolic syndrome
Tabur, S., Oztuzcu, S., Oguz, E. et al.
The contribution of cytochrome P450 (CYP) gene expressions in metabolic syndrome (MetS) has not been elucidated, and was the aim of this study.
A total of 51 MetS patients and 41 healthy controls with similar age and sex were included to this study. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions using a dynamic array system.
We observed marked suppressions in CYP2A6 (p=0.0123), CYP4F2 (p=0.0005), CYP3A5 (p=0.0003), and CYP17A1 (p<0.0001) gene expressions in MetS patients.
This is the first study to provide evidence that depressed expressions of CYP2A6, CYP4F2, CYP3A5, and CYP17A1 genes may play a role in MetS.
Tabur, S., Oztuzcu, S., Oguz, E. et al. "CYP gene expressions in obesity-associated metabolic syndrome" Obesity Research and Clinical Practice (2016): 719–23