Cytometry: Measure for measure
Kling, J.Vaccines are a triumph of science over infection. They have defeated smallpox, which the World Health Organization declared eradicated in 1980, and dramatically lowered the toll of many other infectious diseases. But not all. The search for vaccines against conditions such as HIV/AIDS and malaria has been hindered by researchers' incomplete understanding of the human immune system, says Mario Roederer, an immunologist at the US National Institutes of Health's Vaccine Research Center in Bethesda, Maryland. In general, says Roederer, researchers know that a successful vaccine jump-starts antibody production and other defences. But they do not know which of the immune system's thousand or more functional cell types direct the response against individual pathogens. If researchers could identify those cell types, he says, then they could devise vaccines that maximize production of these cells.
Kling, J. "Cytometry: Measure for measure" Nature (2015): 439–43