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Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis

Elizarov, A.M., van Dam, R.M., Shin, Y.S. et al.

An integrated elastomeric microfluidic device, with a footprint the size of a postage stamp, has been designed and optimized for multistep radiosynthesis of PET tracers.

Methods
The unique architecture of the device is centered around a 5-μL coin-shaped reactor, which yields reaction efficiency and speed from a combination of high reagent concentration, pressurized reactions, and rapid heat and mass transfer. Its novel features facilitate mixing, solvent exchange, and product collection. New mixing mechanisms assisted by vacuum, pressure, and chemical reactions are exploited.

Results
The architecture of the reported reactor is the first that has allowed batch-mode microfluidic devices to produce radiopharmaceuticals of sufficient quality and quantity to be validated by in vivo imaging.

Conclusion
The reactor has the potential to produce multiple human doses of 18F-FDG; the most impact, however, is expected in the synthesis of PET radiopharmaceuticals that can be made only with low yields by currently available equipment.

Citation

Elizarov, A.M., van Dam, R.M., Shin, Y.S. et al. "Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis" Journal of Nuclear Medicine (2010): 282–7