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Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions

Christophersen, A., Lund, E.G., Snir, O. et al.

Combining HLA-DQ–gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.

Citation

Christophersen, A., Lund, E.G., Snir, O. et al. "Distinct phenotype of CD4+ T cells driving celiac disease identified in multiple autoimmune conditions" Nature Medicine (2019): 734-737