Expansion of luminal progenitor cells in the aging mouse and human prostate
Crowell, P.D., Fox, J.J., Hashimoto, T. et al.Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human luminal progenitor cells in BPH. In summary, we define a Trop2+ luminal progenitor subset and identify an age-related shift in the luminal compartment of the mouse and human prostate epithelium.
Crowell, P.D., Fox, J.J., Hashimoto, T. et al. "Expansion of luminal progenitor cells in the aging mouse and human prostate" Cell Reports (2019): doi: 10.1016/j.celrep.2019.07.007