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Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma

Prunicki, M., Stell, L., Dinakarpandian, D. et al.

DNA methylation of CpG sites on genetic loci has been linked to increased risk of asthma in children exposed to elevated ambient air pollutants (AAPs). Further identification of specific CpG sites and the pollutants that are associated with methylation of these CpG sites in immune cells could impact our understanding of asthma pathophysiology. In this study, we sought to identify some CpG sites in specific genes that could be associated with asthma regulation (Foxp3 and IL10) and to identify the different AAPs for which exposure prior to the blood draw is linked to methylation levels at these sites. We recruited subjects from Fresno, California, an area known for high levels of AAPs. Blood samples and responses to questionnaires were obtained (n = 188), and in a subset of subjects (n = 33), repeat samples were collected 2 years later. Average measures of AAPs were obtained for 1, 15, 30, 90, 180, and 365 days prior to each blood draw to estimate the short-term vs. long-term effects of the AAP exposures.

Citation

Prunicki, M., Stell, L., Dinakarpandian, D. et al. "Exposure to NO2, CO, and PM2.5 is linked to regional DNA methylation differences in asthma" Clinical Epigenetics (2018): 2