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Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development

Kury, P., Fuhrer, M., Fuchs, S.

Backgound

The potential of a single progenitor cell to establish and maintain long-term protective T-cell immunity in humans is unknown. For genetic disorders disabling T-cell immunity, somatic reversion was shown to support limited T-cell development attenuating the clinical phenotype. However, the cases reported so far deteriorated over time leaving unanswered the important question of long-term activity of revertant precursors and the robustness of the resulting T-cell system.

Methods

We applied TCRβ-CDR3 sequencing and mass cytometry on serial samples of a now 18 year-old SCIDX1 patient with somatic reversion to analyse the longitudinal diversification and stability of a T-cell system emerging from somatic gene rescue.

Citation

Kury, P., Fuhrer, M., Fuchs, S. "Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development" EBioMedicine (2020): doi.org/10.1016/j.ebiom.2020.102961