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Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity

Singhal, P.K., Sassi, S., Lan, L. et al.

Embryonic fibroblasts have long been considered a relatively homogeneous cell type, and many studies have been conducted on fibroblasts of varying provenance. The results of the present study indicate that embryonic fibroblasts are highly heterogeneous and exhibit anatomic and developmental variation that has both practical consequences for the interpretation of experimental results and theoretical implications for the nature and organization of metazoan organisms. Studies using embryonic fibroblasts to explore the consequences of altered alleles should take into account the possibility that fibroblast composition may be altered by allele expression.

Citation

Singhal, P.K., Sassi, S., Lan, L. et al. "Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity" Proceedings of the National Academy of Sciences of the United States of America (2016): 122–7