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Quantitative measurement of cell-nanoparticle interactions using mass cytometry

Mitchell, A.J., Ivask, A., and Ju, Y.

Mass cytometry is a technique that uses inductively coupled plasma mass spectrometry (ICP-MS) to quantify the isotopic composition of cells in suspension. Traditionally it has been used in conjunction with antibodies labeled with stable lanthanide isotopes to investigate cellular heterogeneity. Here we describe its use to quantify uptake of metal nanoparticles by cells in suspension.

Citation

Mitchell, A.J., Ivask, A., and Ju, Y. "Quantitative measurement of cell-nanoparticle interactions using mass cytometry" Mass Cytometry: Methods and Protocol (2019): 227–41