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Single-cell high-throughput technologies in cerebrospinal fluid research and diagnostics

Lanz, T.V., Pröbstel, A.K., Mildenberger, I. et al.

High-throughput single-cell technologies have recently emerged as essential tools in biomedical research with great potential for clinical pathology when studying liquid and solid biopsies. We provide an update on current single-cell methods in cerebrospinal fluid research and diagnostics, focusing on high-throughput cell-type specific proteomic and genomic technologies. Proteomic methods comprising flow cytometry and mass cytometry as well as genomic approaches including immune cell repertoire and single-cell transcriptomic studies are critically reviewed and future directions discussed.

Citation

Lanz, T.V., Pröbstel, A.K., Mildenberger, I. et al. "Single-cell high-throughput technologies in cerebrospinal fluid research and diagnostics" Frontiers in Immunology (2019): 1302