The potential for elemental analysis in biotechnology
Baranov, V.I., Quinn, Z.A., Bandura, D.R., Tanner, S.D.The ICP-MS brings particular attributes to the method that distinguishes it from organic mass spectrometry: relative insensitivity to concomitant organic or metallic species, equivalent sensitivity to all similarly-tagged complexes, inherent ability to provide absolute quantitation and linearity of response. All these positive features fit the requirements of modern-day biotechnology. In this work, the potential of ICP-MS is discussed in the context of several urgent problems of biotechnology including: the determination of the state of phosphorylation of proteins, quality control of biologically active materials and control of efficiency of cell line transfections.
Baranov, V.I., Quinn, Z.A., Bandura, D.R., Tanner, S.D. "The potential for elemental analysis in biotechnology" Journal of Analytical Atomic Spectrometry (2002): 1,148–52