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The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation

Huang, H., Zhang, X., Zhang, C. et al.

Liver transplantation (LT) provides a cure for various end-stage liver diseases. The liver graft becomes the recipient’s new metabolic center, and donor genetics plays a potent role in the development of complications in the recipient, such as metabolic disorders and even tumor recurrence. Notably, both the donor’s and recipient’s genetics contributes significantly to intrahepatic complications (e.g., liver fibrosis and de novo steatosis). Therefore, crosstalk between donor and recipient tissue remodels the architecture and homeostasis of the transplanted liver, which is still a great challenge to explore.

Citation

Huang, H., Zhang, X., Zhang, C. et al. "The time-dependent shift in the hepatic graft and recipient macrophage pool following liver transplantation" Cellular & Molecular Immunology (2019): doi:10.1038/s41423-019-0253-x.