American Association for Cancer Research
4月 18, 2015
Pennsylvania Convention Center, Philadelphia登録
The foundations of cancer start as a complex interplay between environmental exposure to carcinogens and inherited susceptibility. As cancers progress, heterogeneity increases, creating rare treatment resistant sub-clones with mutational profiles extending beyond even the broadest cancer panels. Without accurately determining how the unique mutations within rare sub-clones affect gene expression and cell function, translational discoveries won’t make it from the bench to the bedside.
You can now unravel cancer complexity by analyzing individual cancer cells at the DNA, RNA, and Protein level, and challenge single-cells with functional studies to determine their biological function. By studying cancer from every angle, you can discover novel biomarkers, build accurate panels, and evaluate the effects of immunotherapy on individual cells.
By enabling single-cell genomic, transcriptomic, proteomic, and functional studies, Fluidigm’s Ideal Lab creates new approaches for cancer breakthroughs. Join us in the Ideal Lab at AACR 2015 booth #763 to learn how you can study cancer from every angle, and rapidly take your research from bench to bedside.
With Fluidigm, Cancer complexity is only in the biology.
Panel Discussion and Mixer
Translating single-cell discoveries into precision therapies
Join us for a panel discussion to learn how the leading single-cell researchers are developing accurate, personalized cancer models.
|Del Frisco’s Wine Vault Map
Monday, April 20, 6:00–9:00 pm
Drinks and heavy appetizers will be served
Fluidigm’s complete end-to-end workflows, single-cell resolution, and high quality data allow you to examine cancer at every angle, and make revolutionary discoveries with confidence.
Access Array™ on Juno
2015 AACR Posters & Presentations
|Richard M. Neve||Cell line authentication to improve preclinical cancer research: Methods in cell line authentication, quality control, and annotation.||Saturday, April 18, 2:00–2:25 PM||Room 108, Pennsylvania Convention Center|
|Michitaka Nakano, Hiroshi Ariyama, Shingo Tamura, et al.||Plasticity of CD44+ colorectal cancer stem cells depends on TGF-beta-induced epithelial mesenchymal transition (EMT): evidences from ex vivo culture system||Monday, April 20, 8:00 AM –12:00 PM||Section 19-19, Abstract #1520|
|Christopher B. Benton, Ahmed Al Rawi, Taejin Min, et al.||Single cell analysis of Lin-CD34-CD45- cells from primary AML samples reveals leukemia clones with stem cell-like properties distinct from CD34+CD38-CD123+ LSC||Monday, April 20, 8:00 AM–12:00 PM||Section 15-3, Abstract #1391|
|Benton et al.||GD2+ breast cancer stem cell growth is dependent on NFκB signaling and suppressed by the IKK inhibitor BMS345541 in vitro and in vivo.||Monday, April 20, 8:00 AM–12:00 PM||Section 19-27, Abstract #1528|
|Paul Savage, Sadiq M. Saleh, Ernesto Iacucci, et al.||Identifying tumor subpopulations and the functional consequences of intratumor heterogeneity using single-cell profiling of breast cancer patient-derived xenografts||Monday, April 20, 1:00 PM–5:00 PM||Section 41, Abstract #LB-129|
|Erin F. Simonds, Garry P. Nolan, William A. Weiss et al.||Characterizing intratumoral cellular heterogeneity in human glioblastoma xenografts by 30+ parameter single-cell mass cytometry||Monday, April 20, 1:00–5:00 PM||Section 17-4, Abstract #2313|
|Jennifer J. Brady, Chen-Hua Chuang, Deborah R. Caswell, et al.||Mechanisms governing lung adenocarcinoma metastasis||Monday, April 20, 1:00–5:00 PM||Section 15-6, Abstract #2255|
|Jakubicova et al.||Phenotypic and molecular characterization of inter- and intraclonal heterogeneity in multiple myeloma and Waldenstrom macroglobulinemia.||Monday, April 20, 1:00–5:00 PM||Section 5-11, Abstract #2004|
|Henry King, Helen Payne, Tim Brend, et al.||Radioresistance in glioma stem cells driven by Rad51 dependent homologous recombination repair||Tuesday, April 21, 8:00 AM–12:00 PM||Section 18-8, Abstract #3303|
|Huanhuan Mahsa He, Feiqiao Brian Yu, Stephen R. Quake, et al.||Single cell analysis of ascites macrophages in ovarian cancer||Tuesday, April 21, 8:00 AM–12:00 PM||Section 14-14, Abstract #3202|
|Emily Putnam, Lam Nguyen, Hunter Chung, et al.||A targeted bisulfite sequencing method combining microfluidics-based PCR with Next-Gen sequencing||Tuesday, April 21, 8:00 AM–12:00 PM||Section 3-14, Abstract #2956|
|Max S. Wicha||Breast cancer stem cell state transitions mediate therapeutic resistance||Tuesday, April 21, 11:40–11:55 AM||Terrace Ballroom II-III (400 Level), Abstract #SY27-03|
|Marco A. De Velasco, Yurie Kura, Naomi Ando, et al.||Inhibition of mouse PTEN-deficient prostate cancer with next generation antisense oligonucleotide targeting the androgen receptor||Tuesday, April 21, 1:00–5:00 PM||Section 20-27, Abstract #4212|
|Mohammad Fallahi-Sichani, Nathan J. Moerke, Mario Niepel, et al.||Single-cell analysis of adaptive resistance and fractional responses of melanoma cells to RAF/MEK inhibition||Tuesday, April 21, 1:00–5:00 PM||Section 1-1, Abstract #3744|
|Shamileh Fouladdel, Hyeun Joong Yoon, Eric Lin, et al.||Gene expression signatures of isolated circulating tumor cells from metastatic breast cancer patients reveal presence of breast cancer stem cells with EMT or MET phenotypes||Tuesday, April 21, 4:20–4:35 PM||Room 118, Abstract #4726|
|Erica B. Schleifman, Maipelo Motlhabi, Craig Cummings, et al.||Comparison of gene expression platforms: RNA-Seq, Fluidigm, and Nanostring||Wednesday, April 22, 8:00 AM–12:00 PM||Section 6-24, Abstract #4901|
|John B. Williamson, Hongyong Zhang, Paul Lott, et al.||A comparison of bulk versus single-cell whole-exome sequencing to study cancer genetic heterogeneity||Wednesday, April 22, 8:00 AM–12:00 PM||Section 3-30, Abstract #4820|
|Ebrahim Azizi, Evelyn M. Jiagge, Shamileh Fouladdel, et al.||Single cell multiplex gene expression analysis to unravel heterogeneity of PDX samples established from tumors of breast cancer patients with different ethnicity||Wednesday, April 22, 8:00 AM–12:00 PM||Section 4-118, Abstract #4834|
|Jun Wang, Guoli Li, Ming Chen, et al.||High-throughput mutation sequencing of the full exon regions in BRCA1 and BRCA2 genes using nanofluidic-PCR prepared libraries||Wednesday, April 22, 8:00 AM –12:00 PM||Section 6-16, Abstract #4893|
Challenge your colleagues to use single-cell methods in their cancer research in the Ideal Lab. Record your challenge to be shared on Twitter and a $10 donation to the American Association of Cancer Researchers will be made in your name.