Epidermal growth factor receptor (EGFR), also known as ErbB-1 and HER1 in humans, is a transmembrane glycoprotein that is a member of the protein kinase superfamily for cell growth and differentiation regulation. EGFR binds to epidermal growth factor and transforming growth factor α (TGFα). Ligand binding induces receptor dimerization and tyrosine autophosphorylation, initiating the MAPK, Akt and JNK signal transduction pathways towards DNA synthesis and cell proliferation. EGFR is expressed or highly expressed in a variety of human tumors of epithelial origin.
Anti-EGFR (D38B1)-142Nd—25 µg