p53 is a 53 kDa protein that operates as a tumor suppressor and helps regulate hundreds of genes in response to various types of stress. DNA binding is critical for the biological functions of p53. p53 can recognize specific DNA sequences or geometries. The sequence-specific DNA binding mainly relates to the transcription function of p53 to selectively bind its transcription targets. The p53 response element (p53RE) or p53 binding sites have two half-site palindromes. The structure of p53 contains an N-terminal transactivation domain, a DNA-binding core domain, a C-terminal tetramerization and a regulatory domain. Proper p53-DNA binding requires a well-folded DNA-binding domain and a p53 homotetramer.
Anti-Human p53 (DO-7)-143Nd—25 µg