The HI186 monoclonal antibody specifically binds to CD52, a 25–29 kDa glycoprotein also known as Cambridge pathology 1 antigen (CAMPATH-1) or human epididymis-specific protein 5 (HE5). CD52 is N-glycosylated, and its C-terminus is glycophosphatidylinositol-anchored in the membrane. It is highly expressed on the surface of thymocytes, mature lymphocytes, monocytes, dendritic cells, eosinophils, and epithelial cells of the epididymis and seminal vesicles. Neutrophils, plasma cells, platelets, and erythrocytes lack expression of CD52. The functional role of CD52 is not well-characterized. However, anti-CD52 antibodies have been employed clinically to remove lymphocytes from transplanted bone marrow.
Anti-Human CD52 (HI186)-146Nd—100 Tests