Lymphocyte activation gene 3 (LAG-3), also known as CD223, is a 70 kDa surface glycoprotein belonging to the Ig superfamily. LAG-3 shares homology with CD4, and LAG-3 binding to MHC class II is thought to contribute to the negative regulation of T cell activation. LAG-3 is expressed on T cells, including regulatory T cells and NK cells. Recently, it has been suggested that co-expression of CD49b and LAG-3 identifies human and mouse type 1 regulatory T (Tr1) cells.
Anti-Human CD223/LAG-3 (11C3C65)-150Nd—100 Tests