Monoclonal antibody P1H12 specifically reacts with CD146, also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). CD146 is a 118 kDa integral transmembrane glycoprotein in the immunoglobulin superfamily. CD146 is expressed on a variety of cell types including melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 has a currently unknown ligand. It has been reported to mediate heterophilic cell adhesion and regulates monocyte transendothelial migration.
Anti-Human CD146 (P1H12)-155Gd—100 Tests