Indoleamine-2,3-dioxygenase (IDO) is an intracellular enzyme that catalayzes the degradation of tryptophan to kynurenines. IDO is expressed in a wide variety of tissues and cells, including macrophages and plasmacytoid dendritic cells. It can also be induced in many different cell types by IFNγ or other inflammatory stimuli. IDO is considered to be an immunosuppressive molecule that limits T cell proliferation and activation through trytophan starvation of T cells. It has been reported that up-regulation of IDO is a mechanism of cancer immune evasion.
Anti-Human IDO (D5J4E)-155Gd—25 µg