CD86 (B7-2) is an 80 kDa member of the B7 family of proteins, which are all transmembrane GPI-linked proteins characterized by extracellular IgV and IgC domains related to the variable and constant Ig domains. All B7 ligands are expressed by antigen-presenting cells (APC) including dendritic cells, macrophages, and B cells, where they play a critical role in regulation of the immune response. While CD86 can bind to the immune-inhibitory receptor CTLA-4, it binds with higher affinity to the immune-stimulatory CD28. CD86 expression on antigen-presenting cells is increased upon activation.
Anti-Human CD86/B7.2 (IT2.2)-156Gd—100 Tests