The MAPK-activated protein kinase 2 (MAPKAPK2, MK2) was discovered as an ERK1/2-activated protein kinase that could phosphorylate heat shock proteins 25 and 27. It was later discovered that MAPKAPK2 is stimulated by p38 in response to stress stimuli. MAPKAPK2 is expressed predominantly in the heart, skeletal, muscle, and kidney tissue and is located mainly in the nuclei of quiescent cells. Upon stimulation, MAPKAPK2 is rapidly exported to the cytoplasm. MAPKAPK2 is activated under various stress conditions that stimulate the p38 isoforms such as UV irradiation, heat shock, oxidative stress, hyperosmolarity, and various cytokines.
Anti-pMAPKAPK2 [T334] (27B7)-159Tb—50 Tests