CD85 is a group of Ig superfamily transmembrane glycoproteins called Ig-like transcripts (ILTs) or leukocyte immunoglobulin-like receptors (LIRs). It is composed of both activating and inhibitory isoforms. The activating subset of ILTs is characterized by containing short cytoplasmic domains and positively charged arginine residues, while the inhibitory isoforms display long cytoplasmic tails containing ITIM motifs. CD85d, also known as ILT4, LIR2, or MIR10, is a 95 kDa inhibitory receptor. ILT4 is expressed on the surface of monocytes, macrophages, and dendritic cells. It acts as an inhibitory receptor through recruitment of SHP-1 and SHP-2 protein tyrosine phosphatases. The ligands of ILT4 are HLA-A, HLA-B, and nonclassical MHC-I molecule HLA-G1.
Anti-Human CD85d/ILT4 (42D1)-161Dy—100 Tests