T cell immunoglobulin mucin-3 (TIM-3) is a type 1 glycoprotein that is expressed on the cells of both innate and adaptive immune system. TIM-3 is expressed by CD4+ Th1 cells but not on CD4+ Th2 cells. TIM-3 is involved in regulating T cell responses by interacting with its ligand galectin-9. TIM-3/galectin-9 signaling is also involved in regulating tolerance to allograft in murine models of transplantation. Dysregulation of TIM-3 in innate immune cells is associated with pathogenesis and exacerbation of disease in chronic viral infections and tumors. TIM-3 also plays a role in the maintenance of tolerance to the fetus.
Anti-Mouse CD366/TIM-3 (RMT3-23)-162Dy—100 Tests