CD95, also known as Fas, APO-1, and TNFRSF6, is a 48 kDa member of the DR family, a subfamily of the tumor necrosis factor receptor superfamily. Members of the DR family are characterized by a cytoplasmic region termed the death domain (DD). Binding of CD95 by its ligand, CD95L (CD178), induces apoptosis in sensitive cells. Ligand binding to CD95 leads to formation of a receptor complex at the cell membrane including FADD/MORT, procaspase-8, procaspase-10, and c-FLIP and results in formation of active caspase-8. CD95 is expressed on T and B lymphocytes, monocytes, neutrophils, and fibroblasts.
Anti-Human CD95/Fas (DX2)-164Dy—100 Tests