The JES10-5A2 antibody binds specifically to human IL-13, an immunoregulatory cytokine produced by activated Th0, Th1, and Th2 lymphocytes. IL-13 is a nonglycosylated protein with a molecular weight of 12 kDa. The IL-13 gene is located in the same region as the genes encoding IL-3, IL-4, IL-5, and GM-CSF. IL-13 shares 30% amino acid sequence homology with IL-4 and can induce similar processes. IL-13 has a diverse range of biological effects including suppression of macrophage cytotoxic activity, up-regulation of IL-1RA expression, suppression of proinflammatory cytokine secretion (IL-1, IL-6, TNF-alpha, and IL-8 ) and prolonging survival of human monocytes. IL-13 is produced by activated CD4+ and CD8+ T cells, but it is expressed in its membrane-bound form primarily on CD4+ T cells.
Anti-Human IL-13 (JES10-5A2)-169Tm—100 Tests