BRCA1 (breast cancer type 1 susceptibility protein) is an important member of the DNA repair pathway, and it functions as a tumor suppressor. It interacts with a wide range of proteins involved in the detection of damaged DNA and activation of appropriate repair pathways, including the Mre11-Rad50-NBS1 (MRN) complex, which is responsible for homologous recombination in the repair of DNA double-stranded breaks. BRCA1 also plays a role in cell cycle regulation, where decreased expression of BRCA1 leads to cell cycle arrest through p53 and p21 genes. BRCA1 and BRCA2 are frequently mutated in cases of hereditary breast and ovarian cancer.
Anti-Human BRCA1 (MS110)-172Yb—25 µg