Members of the STAT (signal transducer and activator of transcription) family are important intracellular messengers of cytokines and growth factor signaling. Seven mammalian STATs have been identified: STAT1-4, 5a, 5b, and 6. STAT proteins are activated by tyrosine phosphorylation, which causes dimerization and translocation to the nucleus, where the STAT dimer acts as a transcription factor. JAK-mediated phosphorylation of Tyr693 on STAT4 occurs in response to several cytokines, including interferon-alpha, IL-12, IL-27, and IL-23. Activated STAT4 promotes transcription of genes that mediate cell growth and survival. STAT4 is considered an important mediator in Th1 and Th17 cell differentiation.
Anti-pStat4 [Y693] (38/p-Stat4)-174Yb—50 Tests