Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Cytokeratin 8 belongs to the type B (basic) subfamily of high-molecular-weight keratins and exists in combination with cytokeratin 18 (type A; acidic subfamily of low-molecular-weight keratins). Keratin isoforms are useful biomarkers for tissue- and differentiation-specific study. Mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases. The C51 monoclonal antibody detects endogenous levels of total keratins 8 and 18 and does not cross-react with other keratins.
Anti-Human Keratin 8/18 (C51)-174Yb—25 µg