1516 検索結果 in 遺伝子発現
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system
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世界で最初のシングルセル遺伝子解析のための自動化システムです。 対応アプリケーションも増えています。 …
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Publications
Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types
Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, but the mechanism generating their diversity remains elusive. …
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Publications
Coordinated Surgical Immune Signatures Contain Correlates of Clinical Recovery
Delayed recovery from surgery causes personal suffering and substantial societal and economic costs. …
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Single-cell technologies for monitoring immune systems
The complex heterogeneity of cells, and their interconnectedness with each other, are major challenges to identifying clinically relevant measurements that reflect the state and capability of the immune system. …
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Efficient molecular subtype classification of high-grade serous ovarian cancer
High-grade serous carcinomas (HGSCs) account for approximately 70% of all epithelial ovarian cancers diagnosed. …
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Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear
In the inner ear, cochlear and vestibular sensory epithelia utilize grossly similar cell types to transduce different stimuli: sound and acceleration. …
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Publications
Transcriptional and Translational Heterogeneity among Neonatal Mouse Spermatogonia
Spermatogonial stem cells (SSCs) are a subset of undifferentiated spermatogonia responsible for ongoing spermatogenesis in mammalian testes. …
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Emerging understanding of multiscale tumor heterogeneity
Cancer is a multifaceted disease characterized by heterogeneous genetic alterations and cellular metabolism, at the organ, tissue, and cellular level. …
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Proceedings: immune tolerance and stem cell transplantation: a CIRM mini-symposium and workshop report
The mission of the California Institute for Regenerative Medicine (CIRM) is to accelerate stem cell treatments to patients with unmet medical needs. …
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Publications
Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients
Acute myeloid leukemia (AML) is a heterogeneous disease. …
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Polyfunctional and IFN-γ monofunctional human CD4+ T cell populations are molecularly distinct
Pathogen-specific polyfunctional T cell responses have been associated with favorable clinical outcomes, but it is not known whether molecular differences exist between polyfunctional and monofunctional cytokine-producing T cells. …
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Publications
Hypoxia-regulated MicroRNAs in Gastroesophageal Cancer
The present study aimed to identify hypoxia-regulated microRNAs (HRMs) in vitro and investigate the clinical role of candidate HRMs in patients with gastroesophageal cancer (GEC). …
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The type I IFN signature as a biomarker of preclinical rheumatoid arthritis
To validate the presence and demonstrate the clinical value of the type I interferon (IFN)-signature during arthritis development. …
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Ischemic pre- and postconditioning has pronounced effects on gene expression profiles in the rat liver after ischemia/reperfusion
Ischemic pre (IPC)- and postconditioning (IPO) protect the liver against ischemia/reperfusion injuries (IRI). …
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Publications
Differential effects of macronutrient content in 2 energy-restricted diets on cardiovascular risk factors and adipose tissue cell size in moderately obese individuals: a randomized controlled trial
The most effective and safe dietary approach for weight loss and its impact on the metabolic functions and morphology of adipose tissue remain unclear. …
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Publications
Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls.
There is persistent uncertainty regarding the developmental origins of coronary vessels, with 2 principal sources suggested as ventricular endocardium or sinus venosus (SV). …
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Serum microRNAs; miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV-positive cirrhosis and hepatocellular carcinoma.
Recently, serum miRNAs have been evolved as possible biomarkers for different diseases including hepatocellular carcinoma and other types of cancers. …
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Use of high-throughput RT-qPCR to assess modulations of gene expression profiles related to genomic stability and interactions by cadmium
Predictive test systems to assess the mode of action of chemical carcinogens are urgently required. …
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Publications
Huntington's disease biomarker progression profile identified by transcriptome sequencing in peripheral blood.
With several therapeutic approaches in development for Huntington's disease, there is a need for easily accessible biomarkers to monitor disease progression and therapy response. …
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Publications
Identification of biomarkers to measure HIV-specific mucosal and systemic CD8(+) T-cell immunity using single cell Fluidigm 48.48 Dynamic arrays.
Thirty genes composed of cytokines, chemokines, granzymes, perforin and integrins were evaluated in gut and splenic K(d)Gag197-205-specific single CD8(+) T cells using Fluidigm 48.48 Dynamic arrays, with the aim of identifying biomarkers to predict effective mucosal and systemic vaccine efficacy. …