1525 検索結果 in 遺伝子発現
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Publications
Nuclear RNA-seq of single neurons reveals molecular signatures of activation
Single-cell sequencing methods have emerged as powerful tools for identification of heterogeneous cell types within defined brain regions. …
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Publications
Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf
The developing kidney provides a useful model for study of the principles of organogenesis. In this report we use three independent platforms, Drop-Seq, Chromium 10x Genomics and Fluidigm C1, to carry out single cell RNA-Seq (scRNA-Seq) analysis of the E14.5 mouse kidney. …
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Publications
Combating subclonal evolution of resistant cancer phenotypes
Metastatic breast cancer remains challenging to treat, and most patients ultimately progress on therapy. …
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Publications
Characteristics of allelic gene expression in human brain cells from single-cell RNA-seq data analysis
Monoallelic expression of autosomal genes has been implicated in human psychiatric disorders. …
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Publications
H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX
We have previously reported a novel O-GlcNAc modification at serine 40 (S40) of H2A (H2AS40Gc). …
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Publications
Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection
Despite potent immunosuppression, clinical and biopsy confirmed acute renal allograft rejection (AR) still occurs in 10–15% of recipients, ~30% of patients demonstrate subclinical rejection on biopsy, and ~50% of them can show molecular inflammation, all which increase the risk of chronic dysfunction and worsened allograft outcomes. …
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Publications
Monitoring and manipulating cellular crosstalk during kidney fibrosis inside a 3D in vitro co-culture
In pharmacological research the development of promising lead compounds requires a detailed understanding of the dynamics of disease progression. …
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Publications
Poly-β-hydroxybutyrate administration during early life: effects on performance, immunity and microbial community of European sea bass yolk-sac larvae
The reliable production of marine fish larvae is one of the major bottlenecks in aquaculture due to high mortalities mainly caused by infectious diseases. …
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Publications
Quantifying engineered nanomaterial toxicity: comparison of common cytotoxicity and gene expression measurements
When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action. …
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Publications
RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations
Activating mutations in the Wnt pathway are a characteristic feature of colorectal cancer (CRC). …
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Publications
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway
Epigenetic mechanisms play important roles in the regulation of tumorigenesis, and hypoxia-induced epigenetic changes may be critical for the adaptation of cancer cells to the hypoxic microenvironment of solid tumors. …
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Publications
Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis
Previous studies have proposed that epithelial to mesenchymal transition (EMT) in breast cancer cells regulates metastasis, stem cell properties and chemo-resistance; most studies were based on in vitro culture of cell lines and mouse transgenic cancer models. …
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Publications
Whole blood stabilization for the microfluidic isolation and molecular characterization of circulating tumor cells
Precise rare-cell technologies require the blood to be processed immediately or be stabilized with fixatives. …
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Publications
Frequency of canine nt230(del4) MDR1 mutation in prone pure breeds, their crosses and mongrels in Israel - insights from a worldwide comparative perspective
Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. …
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Publications
IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
Plasma cell differentiation is a tightly regulated process that requires appropriate T cell helps to reach the induction threshold. …
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Publications
Association of long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus
Increasing evidence has demonstrated the association between long noncoding RNAs (lncRNAs) and multiple autoimmune diseases. …
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Publications
Resolving Species Level Changes in a Representative Soil Bacterial Community Using Microfluidic Quantitative PCR
Rapid advances in genome sequencing technologies enable determination of relative bacterial abundances and community composition, yet, changes at the species level remain difficult to detect despite importance for certain ecological inferences. …
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Publications
Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence
Senescent cells play important roles in both physiological and pathological processes, including cancer and aging. …
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Publications
Identification of genes expressed in a mesenchymal subset regulating prostate organogenesis using tissue and single cell transcriptomics
Prostate organogenesis involves epithelial growth controlled by inductive signalling from specialised mesenchymal subsets. …
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Publications
High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin
Understanding cell type identity in a multicellular organism requires the integration of gene expression profiles from individual cells with their spatial location in a particular tissue. …