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IMCelebrates!

Peer-reviewed publications highlight spatial landscapes and phenotyping

Phenotype

Understanding the presence and location of stromal, tumor and immune cells and how these cells interact in the tissue or tumor microenvironment is key to obtaining new insights into disease pathophysiology and therapeutic response. Here are a few examples that demonstrate how rich Imaging Mass Cytometry™ (IMC™) data has been used to harness the power of high-plex imaging to explore tissue structure, function and phenotype at the single-cell level.
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Phenotype

Uncovering COVID-19 lung pathology

Dr. Olivier Elemento, PhD

Dr. Olivier Elemento, PhD
Director of the Englander Institute for Precision Medicine and Cornell University professor of physiology and biophysics

Weill Cornell scientists recently accomplished an important step forward in understanding lung pathology and immune response to COVID-19 in the Nature publication “The spatial landscape of lung pathology during COVID-19 progression.”

Olivier Elemento, PhD, is Director of the Englander Institute for Precision Medicine and Cornell University professor of physiology and biophysics. A lead researcher of the study and co-senior author of the Nature publication, Elemento commented, “The unique spatial aspects of Imaging Mass Cytometry enabled us to view not only the structure of the tissue but also the interplay between infected cells and the immune system in COVID-19 patients. The diverse range of tissue samples offered incredible insight into the mechanisms of disease progression in these patients, and the rich dataset provided our computational biologists with an opportunity to interpret changes in tissue architecture as well as detect and understand patterns that may provide insights into future approaches to therapies.”

» Read the Weill Cornell press release

» Nature Portfolio webcast: Register for July 13 webinar


Non-random signaling clusters in glioblastoma

Dr. Rebecca Ihrie

Dr. Rebecca Ihrie
Associate Professor of Cell and Developmental Biology at Vanderbilt University

Read about recent work from Rebecca Ihrie, PhD, on her glioblastoma research to identify and associate cell-to-cell variation and distribution within different tumors to phenotypes, extending stratification work done using mass cytometry. Ihrie has benefited from using the Hyperion™ Imaging System in dual mode capacity. In her webinar she highlights how she has performed high-multiplex analysis from both tissue samples and cells in solution.

» Read Spotlight story

» Watch on-demand webinar


Characterization of hepatic adaptive and innate immune sets in hepatitis B virus

Dr. Kyong-Mi Chang

Dr. Kyong-Mi Chang
Professor of Medicine (GI) University of Pennsylvania Perelman School of Medicine

Research led by a group at University of Pennsylvania shows marked correlations between adaptive and innate immune cell frequencies and phenotype, highlighting complex immune interactions within the hepatic microenvironment with relevance to hepatitis B viral pathogenesis. Read the JCI publication “Highly multiplexed 2-dimensional Imaging Mass Cytometry analysis of HBV-infected liver” or watch Kyong-Mi Chang, MD, present a Nature Portfolio webcast to learn more about how the comprehensive phenotypic analysis was performed and correlated with hepatocellular injury, inflammation and fibrosis.

» Read Kyong-Mi Chang's JCI publication

» Watch Nature Portfolio webcast

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