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Uncovering COVID-19 lung pathology
Weill Cornell scientists recently accomplished an important step forward in understanding lung pathology and immune response to COVID-19 in the Nature publication “The spatial landscape of lung pathology during COVID-19 progression.”
Olivier Elemento, PhD, is Director of the Englander Institute for Precision Medicine and Cornell University professor of physiology and biophysics. A lead researcher of the study and co-senior author of the Nature publication, Elemento commented, “The unique spatial aspects of Imaging Mass Cytometry enabled us to view not only the structure of the tissue but also the interplay between infected cells and the immune system in COVID-19 patients. The diverse range of tissue samples offered incredible insight into the mechanisms of disease progression in these patients, and the rich dataset provided our computational biologists with an opportunity to interpret changes in tissue architecture as well as detect and understand patterns that may provide insights into future approaches to therapies.”
Non-random signaling clusters in glioblastoma
Read about recent work from Rebecca Ihrie, PhD, on her glioblastoma research to identify and associate cell-to-cell variation and distribution within different tumors to phenotypes, extending stratification work done using mass cytometry. Ihrie has benefited from using the Hyperion™ Imaging System in dual mode capacity. In her webinar she highlights how she has performed high-multiplex analysis from both tissue samples and cells in solution.
Characterization of hepatic adaptive and innate immune sets in hepatitis B virus
Research led by a group at University of Pennsylvania shows marked correlations between adaptive and innate immune cell frequencies and phenotype, highlighting complex immune interactions within the hepatic microenvironment with relevance to hepatitis B viral pathogenesis. Read the JCI publication “Highly multiplexed 2-dimensional Imaging Mass Cytometry analysis of HBV-infected liver” or watch Kyong-Mi Chang, MD, present a Nature Portfolio webcast to learn more about how the comprehensive phenotypic analysis was performed and correlated with hepatocellular injury, inflammation and fibrosis.
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For Research Use Only. Not for use in diagnostic procedures.